The film was released on March 14, 2008 and was a financial box office success earning worldwide $81,237,529. The film received largely negative reviews. Gigandet and co-star Faris shared an award for "Best Fight" at the 2008 MTV Movie Awards.

In December 2007, Summit Entertainment cast Gigandet in the planned film adaptation of the best selling vampire book series Twilight by Stephenie Meyer. He signed on to portray the role of the film's "tracker" vampire James and its antagonist. The film adaptation was released on November 21, 2008 and followed instant box office success and received mixed reviews from critics. A universally successful film trilogy The Twilight Saga followed. Gigandet did not reprise his role as his character is destroyed at the end of the film. He received his second "Best Fight" award win at the 2009 MTV Movie Awards with Robert Pattinson.

In 2008, Gigandet won the award for "One to Watch" at the 10th Annual Young Hollywood Awards. In August 2008 Gigandet signed on to the Screen Gems supernatural horror film The Unborn portraying the role of the protagonist's love interest. Gigandet stars alongside Meagan Good and Odette Yustman. The film focuses on Yustman's character who is tormented by a ghost which tries to use her death as a gateway to physical existence. The film was produced by Michael Bay's production company Platinum Dunes. The film was released on January 9, 2009 and received universally negative reviews. The film was a financial success earning $75,915,793 worldwide.

In 2010, Gigandet portrayed a supporting role in Screen Gems comedy film Easy A: a 22-year old Christian high school student named Micah. The film was a box office success earning worldwide $76,639,272 worldwide and unanimous critical praise from critics worldwide. That same year Gigandet starred as the villainous prison guard Chase in a psychological study in the Straight-to-DVD thriller The Experiment. The film received mixed reviews from critics.

That same year Screen Gems cast Gigandet in the Golden Globe Award-winning film Burlesque. The film was written and directed by first time Director Steve Antin and stars Cher, Christina Aguilera and Stanley Tucci. The film is a musical film which follows Christina Aguilera's character who moves to Los Angeles to pursue her dream of singing and ends up in a burlesque bar. Gigandet portrays Christina's love interest, Jack, a bartender who works at the club. The film was released on to November 24, 2010 to mixed reviews. The film was a box office success as of February 2011 earning more than $89 million worldwide.

In 2009, Gigandet was cast alongside Leighton Meester and Minka Kelly in the thriller film The Roommate. The film followed a college freshman who is randomly assigned to the roommate from hell who soon becomes obsessed. He played Stephen, a University student and love interest of Minka's character. The film received numerous push-backs and was released on February 4, 2011. It has been compared to the film Single White Female by the media.

In May 2010, 20th Century Fox cast Gigandet in the psychological thriller Trespass alongside Nicole Kidman and Nicolas Cage. Gigandet will portray the leading antagonist who takes the married couple portrayed by Nicole and Nicolas's characters hostage. Filming took place throughout August and September 2010. The film is set to be released sometime in 2011. In March 2009, Gigandet was cast in a major supporting role in the Screen Gems action horror film Priest. Gigandet portrayed the role of Hicks, a Wasteland Sheriff. The film was pushed back numerous times, and released on May 13, 2011, shown in 3D.

Gigandet and his girlfriend, Dominique Geisendorff, had a daughter, Everleigh Rae Gigandet, on April 14, 2009. In an early 2011 interview, he referred to Geisendorff as his "wife." He is a practitioner of Krav Maga, a self-defense system developed by the Israeli army.

Filmography:
2009 : The Unborn ; Pandorum
2010 : Five Star Day ; Easy A ; Burlesque ; The Experiment (film)
2011 : The Roommate; Pries ; Trespass