When, in 1826, Poe entered the newly opened University of Virginia, Allan's allowance was so meager that Poe turned to gambling to supplement his income. In 8 months he lost $2, 000. Allan's refusal to help him led to total estrangement, and in March 1827 Poe stormed out on his own.

Poe managed to get to Boston, where he signed up for a 5-year enlistment in the U.S. Army. In 1827, as well, he had his Tamerlane and Other Poems published at his own expense, but the book failed to attract notice. By January 1829, serving under the name of Edgar A. Perry, Poe rose to the highest noncommissioned rank in the Army, sergeant major. He was reluctant to serve out the full enlistment, however, and he arranged to be discharged from the Army on the understanding that he would seek an appointment at West Point. He thought that such a move might cause a reconciliation with his guardian. That same year Al Araaf, Tamerlane and Minor Poems was published in Baltimore and received a highly favorable notice from the novelist and critic John Neal. Armed with these new credentials, Poe visited Allan in Richmond, but another violent quarrel forced him to leave in May 1830.

The West Point appointment came through the next month, but, since Poe no longer had any use for it, he did not last long as a cadet. Lacking Allan's permission to resign, Poe sought and received a dismissal for "gross neglect of duty" and "disobedience of orders." His guardian, long widowed, had taken a young wife who might well give him an heir, and Poe realized that his hopes of a legacy were without foundation.

During his early years of exile Poe had lived in Baltimore for a while with his aunt Maria Clemm and her 7-year-old daughter, Virginia. He returned to his aunt's home in 1831, publishing Poems by Edgar Allan Poe and beginning to place short stories in magazines. In 1833 he received a prize for "MS. Found in a Bottle, " and John Pendleton Kennedy got him a job on the Southern Literary Messenger. In 1836 Poe married his cousin Virginia—now 13 years old—and moved to Richmond with his bride and mother-in-law. Excessive drinking lost him his job in 1837, but he had produced prolifically for the journal. He had contributed his Politian, as well as 83 reviews, 6 poems, 4 essays, and 3 short stories. He had also quintupled the magazine's circulation. Rejection in the face of such accomplishment was extremely distressing to him, and his state of mind from then on, as one biographer put it, "was never very far from panic."

The panic accelerated after 1837. Poe moved with Virginia and her mother to New York, where he did hack work and managed to publish The Narrative of Arthur Gordon Pym (1838). Then they moved to Philadelphia, where Poe served as coeditor of Burton's Gentleman's Magazine. In 2 years he boosted its circulation from 5, 000 to 20, 000 and contributed some of his best fiction to its pages, including "The Fall of the House of Usher." In 1840, furthermore, he published Tales of the Grotesque and Arabesque. But there was trouble at Burton's, and in 1841 Poe left for the literary editorship of Graham's Magazine.

It was becoming clear that 2 years was about as long as Poe could hold a job, and his stay at Graham's confirmed this principle. Though he contributed skillfully wrought fiction and unquestionably developed as a critic, his endless literary feuding, his alcoholism, and his inability to get along very well with people caused him to leave after 1842.

The Murders in the Rue Morgue and The Man That Was Used Up emerged in 1843, and a Philadelphia newspaper offered a $100 prize for his "The Gold Bug, " but Poe was now facing a kind of psychological adversity against which he was virtually helpless. His wife, who had been an absolutely crucial source of comfort and support to him, began showing signs of the consumption that would eventually kill her. When his burden became too great, he tried to relieve it with alcohol, which made him ill.

After great struggle Poe got a job on the New York Mirror in 1844. He lasted, characteristically, into 1845, switching then to the editorship of the Broadway Journal. Although he was now deep in public literary feuds, things seemed to be breaking in his favor. The 1844 publication of the poem "The Raven" finally brought him some fame, and in 1845 the publication of two volumes, The Raven and Other Poems and Tales, both containing some of his best work, did in fact move him into fashionable literary society. But his wife's health continued to deteriorate, and he was not earning enough money to support her and Clemm.

Poe's next job was with Godey's Lady's Book, but he was unable to sustain steady employment, and amid the din of plagiarism charges and libel suits, his fortunes sank to the point that he and his family almost starved in their Fordham cottage in the winter of 1846. Then, on Jan. 30, 1847, Virginia Poe died.