Sever, and Party Monster with former Home Alone star Macaulay Culkin went virtually unseen by the general public. 2003's Charlie's Angels: Full Throttle placed Liu firmly back inside the spotlight, though she was somewhat overshadowed by the toothy blonde glint that is Cameron Diaz. Luckily for Liu, she was given the chance to shine quite independently when Quentin Tarantino cast her as the deadly O-Ren Ishii, AKA Cottonmouth, in Kill Bill Vol. 1 (2003).

Her film 3 Needles was released on December 1, 2006. In the film, she plays Jin Ping, an HIV-positive Chinese woman. Liu agreed to star in the film for lower than usual pay because she wanted to spread awareness about the way AIDS is improperly treated in China and Thailand. Liu's other recent roles, which met with less success, but later gain cult followings among her fans, include Code Name: The Cleaner, an action comedy released January 5, 2007; Rise, a supernatural thriller co-starring Michael Chiklis in which Liu plays an undead reporter (for which she was ranked number forty-one on "Top 50 Sexiest Vampires"); and Watching the Detectives, an independent romantic comedy co-starring Cillian Murphy. Liu has also signed on to star in a new version of Charlie Chan which has been in pre-production since 2000; she will produce both films.

Liu has guest starred as lawyer Grace Chin on Ugly Betty in the episodes "Derailed" and "Icing on the Cake". In a 2001 episode of Sex and the City entitled "Coulda, Woulda, Shoulda" she guest starred as herself, playing a new client of character Samantha Jones, who does public relations. She starred in the Sex and the City inspired TV show, Cashmere Mafia on ABC. In 2007, Empire magazine named her among the "100 Sexiest Movie Stars".

In 2008, after pitching an interest in being part of the hit new show Dirty Sexy Money, the producers immediately created a role for her as a series regular. She played the role of Nola Lyons, a powerful attorney that faced Nick George (played by Peter Krause).[13] She is the voice for Silvermist in Disney Fairies franchise. She also appeared in Kung Fu Panda, an animated film in which she voiced Viper.

March 2, 2010, Liu made her Broadway debut in the Tony Award-winning play God of Carnage playing Annette as part of the second replacement cast along side Jeff Daniels, Janet McTeer and Dylan Baker.

Television:

1996–1997 Pearl
1998–2002 Ally McBeal
2004 Game Over
2004–2010 Maya and Miguel
2008 Cashmere Mafia
2008–2009 Dirty Sexy Money
2009 Afro Samurai Resurrection
2010 Marry Me