Omar Hashim Epps was born in Brooklyn, New York. His parents divorced during his childhood and he was raised by his mother, Bonnie Maria Epps, an elementary school principal. He lived in several neighborhoods while growing up (Bedford-Stuyvesant, East New York and Flatbush). Before he started acting, he belonged to a rap group called Wolfpack which he formed with his cousin in 1991. He began writing poetry, short stories and songs at the age of ten and attended the Fiorello H. LaGuardia High School of Music & Art and Performing Arts.

Epps has a daughter, Aiyanna, from a previous relationship. He married Keisha Spivey from the R&B group Total in 2006. They live in California with daughter K'mari Mae (born July 2004) and son Amir (born 25 December 2007).

He made his feature film debut with rapper Tupac Shakur as the star of cinematographer Ernest Dickerson's directorial film debut Juice. The film is the violent and tragic story of four young men growing up in Harlem.

Epps followed up his performance in Juice as a running back in the college football drama The Program alongside James Caan.

Epps starred in the film "Deadly Voyage" produced by John Goldschmidt for HBO Pictures and BBC Films, and won the best actor award at the Monte Carlo Television Festival for portraying Kingsley Ofusu in this true story about African stowaways.

The following year, he switched to baseball as co-star of Major League II, taking over the role of Willie Mays Hayes from originator Wesley Snipes. His next athletic endeavor was playing a track and field star in John Singleton's Higher Learning, a look at the politics and racial tensions of college life.

Epps landed a role on the hit television drama ER for several episodes portraying Dr. Dennis Gant, a troubled surgical intern. After his television work on ER, Epps returned to the big screen in 1997 with a brief turn as a giddy moviegoer on a date with a woman played by Jada Pinkett, who ends up an early victim of a psycho slasher in the blockbuster sequel Scream 2