Mowry enjoyed working with her twin and their comedic chemistry was evident on screen.

While filming "Sister, Sister," the Mowry twins starred alongside brother Tahj in the movie "Seventeen Again" (2000). The story of a grandmother who drank a special formula that turned her 17 again, resulted in lots of laughs for both the audience and the cast. It was a delight to watch the three Mowry siblings showcase their acting talents. She followed that project with the movie "Something to Sing About" (2001), acting alongside Irma P. Hall and another ABC sitcom alum, Darius McCrary from "Family Matters" (ABC, 1989–1998) fame.

Education was always a big part of Mowry's life. She attended Birmingham High School in Van Nuys, CA. In 2001, Mowry graduated from Pepperdine University in Malibu, CA with a degree in Psychology, along with her sister. They spent the summer of 2001 at the university's campus in Florence, Italy.

The twins hit the big time in 2002 by joining the cast of "The Hot Chick." The comedy starred "Saturday Night Live" (NBC, 1975– ) alum Rob Schneider and Rachel McAdams, but it was the twins who lit up the screen every time they appeared.

Mowry took on a solo project in 2004 when she joined the cast of "Strong Medicine." She played Dr. Kayla Thorton for several episodes and proved she was a veritable dramatic actor. Her sister later made a guest appearance in an episode titled "My Sister, My Doctor, Myself" (2006).

In 2005, Mowry and her sister filmed the movie "Twitches" (Disney Channel). The plot was very similar to "Sister, Sister," with a magical twist. They were twin witches who got separated at birth. Mowry played Camryn Barnes/Apolla. Kristen Wilson played the girls' mother, even though in reality, she was only nine years older than them. Mowry made a return to TV comedy in 2006 when she voiced the character of Esther in four episodes of the hit animated series, "Family Guy" (FOX, 1999– ).