In 2005, her design won the competition for the new city casino of Basel, Switzerland. In 2004 Hadid became the first female recipient of the Pritzker Architecture Prize, architecture's equivalent of the Nobel Prize. Previously, she had been awarded a CBE for services to architecture. She is a member of the editorial board of the Encyclopædia Britannica. In 2006, Hadid was honored with a retrospective spanning her entire work at the Guggenheim Museum in New York. In that year she also received an Honorary Degree from the American University of Beirut.

Zaha Hadid's architectural design firm - Zaha Hadid Architects - is over 250 people strong, headquartered in London.

In 2008, she ranked 69th on the Forbes list of "The World's 100 Most Powerful Women". On 2 January 2009, she was the guest editor of the BBC's flagship morning radio news programme, Today.

In 2010 she was also named by Time magazine as influential thinker in the 2010 TIME 100 issue.

Hadid is the designer of the Dongdaemun Design Plaza & Park in Seoul, South Korea, which is expected to be the centerpiece of the festivities for the city's designation as World Design Capital 2010. The complex is scheduled to be completed in 2011.

She has also undertaken some high-profile interior work, including the Mind Zone and Feet zone at the Millennium Dome in London and the Z.CAR hydrogen-powered, three-wheeled automobile. In 2009, she worked with the clothing brand Lacoste, to create a new, high fashion, and advanced boot.

In 2007, Zaha Hadid designed the Moon System Sofa for leading Italian furniture manufacturer B&B Italia.

Architectural work

Conceptual projects
* Price Tower extension hybrid project (2002), Bartlesville, Oklahoma - pending
* Guggenheim-Hermitage Vilnius, Vilnius, Lithuania, (2008-) - not realized
* Kartal-Pendik Waterfront Regeneration, Istanbul, Turkey
* Szervita square bubble office building Budapest, Hungary - not realized

Completed projects
* Vitra Fire Station (1994), Weil am Rhein, Germany
* Hoenheim-North Terminus & Car Park (2001), Hoenheim, France
* Bergisel Ski Jump (2002), Innsbruck, Austria
* Rosenthal Center for Contemporary Art (2003), Cincinnati, Ohio
* BMW Central Building (2005), Leipzig, Germany
* Ordrupgaard annexe (2005), Copenhagen, Denmark
* Phaeno Science Center (2005), Wolfsburg, Germany
* Maggie's Centres at the Victoria Hospital (2006), Kirkcaldy, Scotland
* Tondonia Winery Pavilion (2001–2006), Haro, Spain
* Eleftheria square, redesign (2007), Cyprus
* Hungerburgbahn new stations (2007), Innsbruck, Austria
* Chanel Mobile Art Pavilion (Worldwide) Tokyo, Hong Kong, New York, London, Paris, Moscow, (2006–2008)
* Bridge Pavilion (2008), Zaragoza, Spain
* J. S. Bach Pavilion, Manchester International Festival (2009), Manchester, UK
* CMA CGM Tower, Marseille, France, (2007–2009)
* Pierres vives, Montpellier, France, (2002–2012)

Ongoing and future projects
* MAXXI - National Museum of the 21st Century Arts in Rome. (1998-2010)
* Napoli Afragola railway station, Italy (completion delayed to 2011)
* Nuragic and Contemporary art museum (2006) (under construction), Cagliari, Italy
* Riverside Museum (2007–2011) (projected) development of Glasgow Transport Museum, Scotland
* Eli and Edythe Broad Museum, Michigan State University, (2008-12)
* Mandarin Oriental Dellis Cay, Villa D (2012) (private home under construction), Dellis Cay, Turks & Caicos Islands
* London Aquatics Centre, London, UK, (2008–2013), a 17,500-seat venue for the 2012 Summer Olympics.
* Heydar Aliyev Cultural Centre in Baku, Azerbaijan.
* Dongdaemun Design Plaza & Park in Seoul, South Korea.

Other work includes the new departmental records building, Pierres vives, for Hérault in Montpellier. Zaha Hadid's project was named as the best for the Vilnius Guggenheim Hermitage Museum in 2008. She designed the Innovation Tower for Hong Kong Polytechnic University, scheduled for completion in 2011, and the Chanel Mobile Art Pavilion that was displayed in Hong Kong in 2008. She has been commissioned to design new buildings for Evelyn Grace Academy, Brixton.